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PEBC: What You Need to Know: Acetylcholinesterase Inhibitors

Examples: donepezil, galantamine, rivastigmine

Indication: dementia


Donepezil and galantamine: once daily

Rivastigmine: twice daily

Adverse Effects:


-nausea and vomiting


-urinary frequency

-nightmares or insomnia

-may affect asthma/chronic obstructive pulmonary disease

Drug Interactions:

-beta-blockers and diltiazem/verapamil - increased risk of bradycardia

-donepezil and galantamine levels may be increased by CYP2D6 (ex. terbinafine) and CYP3A4 inhibitors (ex. clarithromycin)

-rivastigmine has low risk of drug interactions

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