Examples (ones that do not fit into SSRI or SNRI categories): vortioxetine, vilazodone, trazodone, bupropion, mirtazapine
Dosing:
-all can be dosed once daily
-bupropion sustained-release is given twice daily, whereas extended-release is once daily
Adverse Effects:
-dry mouth, constipation (mirtazapine, bupropion)
-nausea (vortioxetine)
-diarrhea (vilazodone)
-dizziness (vortioxetine, trazodone)
-insomnia (bupropion, vortioxetine)
-drowsiness (trazodone, mirtazapine)
-weight gain (less with bupropion)
-seizures (bupropion)
-QT prolongation
Drug Interactions:
-Contraindicated with MAO inhibitors - ensure 14 days between stopping MAOI and starting new agent
-serotonin syndrome with other triptans, tricyclic antidepressants (not a problem for bupropion since it only affects dopamine and norepinephrine)
-bupropion is a CYP2D6 inhibitor itself