Examples: Sitagliptin, Saxagliptin, Alogliptin, Linagliptin
Dosing:
-once daily (split into twice daily when combined with metformin)
-with or without food
-reduce dose in kidney impairment
Adverse Effects:
-weight neutral
-headache, nausea
-altered bowel movements (diarrhea or constipation)
-increased infection risk
-nasopharyngitis
-rare: joint pain
-rare: pancreatitis
-saxagliptin: may induce heart failure
Drug Interactions:
-alogliptin and sitagliptin have minimal
-linagliptin and saxagliptin may be affected by CYP3A4 system