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PEBC: What You Need to Know: Fibrates

Examples: Fenofibrate, bezafibrate, gemfibrozil


Indication: elevated triglycerides (and to some extent, reduces LDL cholesterol and increases HDL cholesterol)


Dosing:

Fenofibrate and bezafibrate: once daily

Gemfibrozil: twice daily before meals


Adverse Effects:

-myopathy

-gastrointestinal upset

-abdominal pain

-increased liver function tests

-gallstones


Drug Interactions:

-increased risk of rhabdomyolysis with statins and colchicine

-gemfibrozil is an inhibitor of CYP2C8/2C9, careful with substrates such as sulfonylureas, repaglinide and rosiglitazone


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