Examples:
Irreversible: phenelzine, tranylcypromine
Reversible: moclobemide
Indication: Depression
(usually not first-line due to adverse effects and drug interactions)
Adverse Effects: (Many!)
-insomnia
-nausea
-orthostatic hypotension
-sexual dysfunction
-tremor
-restlessness
-headache
-dry mouth
Drug Interactions:
-any serotonin agent (SSRI, SNRI, TCA, dextromethorphan, alcohol, triptans)
--> leads to serotonin syndrome and hypertensive crisis (confusion, tachycardia, fever)
*diet restrictions involving tyramine (can lead to hypertensive crisis)