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PEBC: What You Need to Know: MAO-A Inhibitors


Irreversible: phenelzine, tranylcypromine

Reversible: moclobemide

Indication: Depression

(usually not first-line due to adverse effects and drug interactions)

Adverse Effects: (Many!)



-orthostatic hypotension

-sexual dysfunction




-dry mouth

Drug Interactions:

-any serotonin agent (SSRI, SNRI, TCA, dextromethorphan, alcohol, triptans)

--> leads to serotonin syndrome and hypertensive crisis (confusion, tachycardia, fever)

*diet restrictions involving tyramine (can lead to hypertensive crisis)

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