PEBC: What You Need to Know: Methotrexate

Indications: Rheumatoid arthritis, psoriasis, certain cancers

Dose: most of the time weekly or cyclical basis

-tablets: with food to reduce nausea

-may be given subcutaneously, intramuscularly and intravenously depending on indication

-large doses require adequate hydration (for kidney protection)


-pregnancy (off-label it is used to induce abortion)

Adverse Effects:

-mouth ulcers, gastric ulcers and nausea - due to folate depletion - supplement with folic acid at least 24 hours after methotrexate dose



-renal failure: adequate hydration is key