PEBC: What You Need to Know: Resins

Examples: Cholestyramine, Colestipol, Colesevelam

Indications:

-dyslipidemias

-diarrhea

-pruritus due to biliary disorders

Dosing:

-divided doses: once to three times daily

-with food (reduces upset stomach)

-dry powders should be mixed with water

Adverse Effects:

-nausea, bloating, gas, flatulence

-constipation (take more fibre)

-may increase triglycerides

-may increase liver function tests

-rare: hyperchloremic acidosis

Drug Interactions:

-resins tend to bind to other medications: administer other medications 1 hour before or 4 to 6 hours after resin