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PEBC: What You Need to Know: Thiazide Diuretics

Examples: Hydrochlorothiazide, Chlorthalidone, Indapamide

Dosing: once daily in the morning (due to urinary diuresis effect)

Efficacy: one of the first line drugs for hypertension: antihypertensive effect seen at half of the maximum dose (ceiling effect). Less effective in reduced creatinine clearance.

Adverse Effects:

-Electrolyte abnormalities: hyponatremia, hypokalemia



-May increase glucose or lipid levels

Drug Interactions:

-increased QT prolongation risk with other drugs: due to diuretic-induced hypokalemia

-lithium: diuretics may lead to increased lithium reabsorption and toxicity

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