PEBC: What You Need to Know: Thiazide Diuretics

Examples: Hydrochlorothiazide, Chlorthalidone, Indapamide


Dosing: once daily in the morning (due to urinary diuresis effect)


Efficacy: one of the first line drugs for hypertension: antihypertensive effect seen at half of the maximum dose (ceiling effect). Less effective in reduced creatinine clearance.


Adverse Effects:

-Electrolyte abnormalities: hyponatremia, hypokalemia

-Gout

-Photosensitivity

-May increase glucose or lipid levels


Drug Interactions:

-increased QT prolongation risk with other drugs: due to diuretic-induced hypokalemia

-lithium: diuretics may lead to increased lithium reabsorption and toxicity

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