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PEBC: What You Need to Know: Thiazolidinediones (TZD)

Examples: Pioglitazone, Rosiglitazone


Indication: Diabetes


Mechanism: increases insulin sensitivity


Dosing: Once to twice daily

Role in Therapy:

Very rarely used nowadays - due to emerging evidence of safey concerns (see adverse effects)


Adverse Effects:

-edema

-weight gain

-may preciptiate out heart failure

-increased fracture risk

-bladder cancer (? pioglitazone)

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