Theme of the Week: Frequent Dosing Drugs

Nobody likes to take many pills, and nobody wants to take a pill more frequently than required. Imagine this: a patient has to take a pill four times a day - the likelihood of non-adherence is high compared to once daily dosing. It’s just not convenient and easy to remember.


Here are four of the most notoriously frequently dosed medications. Keep these in mind when suggesting medications to help simplify a patient’s regimen.

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1) Antibiotics: Cephalexin, Cloxacillin, Ampicillin, Clindamycin and Quadruple H.Pylori Regimen: All of these antibiotics are dosed four times daily, which is quite inconvenient, especially if you have to time them around meals (some are with food, while others are on an empty stomach).


2) Acyclovir: When used as viral treatment, this medication is dosed up to 5 times a day. There are better alternatives such as valacyclovir and famciclovir which have three times daily dosing.


3) Levodopa: because of its short half life, it has to be dosed up to 6 times a day for Parkinson's Disease. In fact, because of this reason, it has to be combined with a peripheral inhibitor to increase blood circulatory levels.


4) Isosorbide Dinitrate and Hydralazine: This is a common combination used for heart failure patients, where both can be dosed four times daily.





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