top of page

PEBC: What You Need to Know: ACE Inhibitors (-pril) and ARBs (-tan)

Updated: Jul 25, 2020

Examples: Ramipril and Candesartan


  • Hypertension

  • Heart failure

  • Kidney disease

  • Stroke

  • Myocardial Infarction

Adverse Effects:

  • Dizziness

  • Dry Cough: most common drug-induced cough cause → switch to ARB instead which has less risk

  • Angioedema: swelling of face and lips, rare but unique

  • Hyperkalemia

  • Acute renal failure (if dehydrated)

  • Increased serum creatinine

  • Contraindicated in pregnancy

Drug Interactions:

  • Lithium: increased lithium levels by up to 50%

  • Medications that increase potassium levels (potassium supplements, potassium-sparing diuretics - spironolactone, sulfamethoxazole-trimethoprim): hyperkalemia

  • NSAIDs - increases blood pressure and kidney dysfunction

  • Do not combine Aliskiren (direct renin inhibitor), ACE inhibitor and ARB due to hypotension, angioedema and renal dysfunction

16 views0 comments


bottom of page